Central Nervous System

Perceptive has many years of experience supporting preclinical CNS drug discovery and development programs. Our tissue biomarker services along with our functional and molecular imaging solutions are well-suited for non-invasive longitudinal studies to provide multiple readouts, such as biodistribution, target-occupancy relationships, and therapeutic efficacy.

• Biodistribution
• Target Engagement & Occupancy Studies
• Neuropharmacodynamics
• Neurotransmitter Release
• Biological Therapeutics Pharmacokinetics
• Neuroinflammation
• Neuromodulator Analysis

We support a wide range of first-in-human, pre-proof of concept CNS clinical trial imaging studies spanning phases I-IIa.

MRI

• Brain volumetric analysis
• Changes in brain activity and cerebral blood flow
• Tissue microstructure
• Tissue susceptibility
• Pharmacodynamic responses

PET

• Radioligand dosimetry
• Quantitative drug brain distribution
• Target engagement
• Drug concentration – Target occupancy relationship
• Pharmacodynamic responses

Perceptive’s Late Phase (IIb-IV) CNS clinical trial imaging capabilities enable the execution and delivery of large-scale clinical trials for diagnosis, progression, and disease monitoring through optimized study design, world-wide imaging site set up, iPACs driven data management and quantitative analytics. This end-to-end service is deployed in the necessary regulatory infrastructure to deliver clinical trial results ready for regulatory filing.

• Core lab capabilities with complete project support
• Clinical imaging center evaluation, selection, set up, training and management
• Rapid analysis for study eligibility
• Quantitative analysis for monitoring drug effect
• Image data management and regulatory compliance services

We develop advanced algorithms and pipelines to solve complex image science problems, including the use of machine learning and deep learning techniques. These methods are built on our deep scientific domain knowledge to deliver optimal analytical performance and relevant biological outcome measures for a variety of tasks, including:

• IQ Analytics Suite – Tau, Amyloid and DaT Imaging
• Batch Image Triage & QC
• Tracer Kinetic Analysis
• Biomathematical Modeling
• Image Registration, Segmentation and Volumetric Analysis
• Radiation Dosimetry